Weight loss methods have been advanced with the help of modern medication. It all started with exercising, and healthy diets. Not with the introduction of peptides, insulin control, and weight loss have been taken to another level. With the application of peptide drugs, people with obesity do not find it as challenging as it was earlier.
Obesity and overweight remain a concerning factor for the whole of America. The obesity rates keep soaring year after year. This indicates that the chances of heart strokes increase associated with diabetes. Over the long run, diabetes can impair the central nervous system, shutting down all the power supply to various organs. People with higher body mass index have higher chances of cardiovascular issues.
However, with the approval of a new peptide drug, weight loss benefits seem promising. Earlier, peptide drugs were shown effective in controlling blood sugar levels. Recently, a new drug called Tirzepatide has been introduced which is approved by the FDA administration to help lose weight and regulate insulin levels.
Key Takeaways
- Mechanism: Tirzepatide mimics incretin hormones to regulate insulin, reduce liver glucose production, and curb appetite.
- Effectiveness: Clinical trials show significant weight loss, with an average of 15-20% reduction over 72 weeks.
- Considerations: FDA-approved for BMI 30+, but may cause side effects; not suitable for certain groups like pregnant women or those with thyroid cancer history.
What Is Tirzepatide?
Tirxepatide is a GLP-1 receptor agonist shown to reduce blood sugar levels and increase energy conversion by activating the growth hormone. This medication works by copying the mechanism of incretin hormones, GLP-1 and GIP, which are released after eating.
It works by stimulating the production of insulin and signals the liver to lower the amount of glucose it produces. At the same time, it signals the brain to reduce appetite by prompting a feeling of fullness.
Tirzepatide was earlier approved to treat Type 2 diabetes by the FDA and was launched under the brand name Mounjaro. Around last year November, an upgraded version of Tirzepatide was released, it also earned approval for weight management with or without diabetes. This version was launched under the brand name Zepbound.
How Effective Is It?
The FDA has approved this medication for the sole purpose of managing weight because of its effectiveness. The effectiveness of this drug may vary from one individual to another.
According to the clinical trials of around 2,500 obese or overweight people. Those injected with the medication on a clinical dosage had an average weight loss of 15% to 20% of their initial weight. This trial was over 72 weeks of regular dosage. Moreover, those who took a higher dosage of Trizepatide have lost at least 25% of their body weight
What Are The Conditions To Take Tirxepatide?
Tirzepatide is approved for clinical use for those struggling with obesity and being overweight. The FDA-approved instruction only suggests this drug as a weight loss medication only if the body mass is 30 or more and in case of additional weight-associated health conditions such as diabetes, cholesterol, and, others.
Are There Any Side Effects?
Yes, like every medication, Trizepatide causes slight side effects. Side effects seem to occur during the early stage of medication. This might be due to the body’s immune response to the new medication. Side effects were also shown on some when the dosage of the medication was increased. These side effects resolve over time.
Some of the common side effects of Trizepatide are given below:
- Vomiting
- Nausea
- Gastrointestinal issues
- Stomach ache
- Constipation
- Loss of appetite
However, in case of any severe side effects, it is best advised to consult a personal health care provider before attempting any action.
Who Should Not Use Trizepatide?
This weight management drug is not appropriate for those who have a history of thyroid cancer. Some studies show that it rejuvenated thyroid cell tumors in animals, but no indication of such was shown in humans. So, experts have suggested not to implement the application of Trixepatide in case of Thyroid symptoms.
Patients with severe allergic conditions must avoid using this medication as it can cause breathing difficulties due to allergic reactions. In such circumstances, immediate medical attention is required.
Pregnant women, lactating mothers, and kids below 18 years of age are not suitable to take this medication because of the hormonal changes in their bodies. Those who are awaiting surgeries must avoid the medication. It can also interact with other medications. So make sure to review the possibility of interaction in case you are taking medication.
Final Words
Tirzepatide is an FDA-approved weight loss medication directed to be injected weekly to control blood sugar levels. It is also suitable for weight management for obese and overweight people.
It helps the body control the blood sugar levels and manage weight by signaling the brain that it is already full and slowing the digestion to stop hunger, in this way it helps to manage the weight.
Despite the approval from the Food and Drug Administration, the best results can be achieved by incorporating a healthy weight loss meal plan and regular exercise. It can lead to significant weight loss when it is injected as per the clinical dosage.
