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NanoDefense Pro Reviews 2024: (Nail Support Formula) Observations After Authentic Testing!

Are you someone who is struggling with toenail fungus? Do you feel exhausted after trying out every available medication and supplement for treating it? If ...

by Sarah Waldorf

Are you someone who is struggling with toenail fungus? Do you feel exhausted after trying out every available medication and supplement for treating it? If yes, you have come to the right place. NanoDefense Pro is a name that has been getting much recognition among online circles for being a healthy nail formula.

Many discussions have been surrounding this formula and its various properties. Through one such unofficial debate that happened on Reddit, I came across this supplement for the first time. Having experience as a professional medical reviewer for the past few years,  I got hooked on the claims made by its manufacturers. I devised this NanoDefense Pro review for this very purpose.

NanoDefense Pro Reviews: Do The Claims Correspond With Reality? Find Out!

NanoDefense Pro foot microbiome support formula claims to combine advanced nanotechnology with conventional herbal medicine. I decided to examine these claims by implementing a thorough research where I collected data from various sources. To get a firsthand look at the supplement, I even sought the help of a supplement testing company where the formula was tested under expert guidance for 30-35 days.

This NanoDefense Pro review unravels everything about the supplement where each section is divided into a product overview, working mechanism, ingredient analysis, pros and cons comparison, dosage guidelines, and many more. So go into the review and find out everything you need to know about this nail care solution!

NanoDefense Pro Review
NameNanoDefense Pro
TypeFoot microbiome support formula
Distinctive Features▪️ Uses nanotechnology in skincare
▪️ Manufactured in the USA
▪️ FDA-registered facility
▪️ Follows GMP-certified practice
▪️ Free from GMOs
CompositionLiquid solution
Net Weight15 ml/0.5 FL.OZ
Main Ingredients▪️ Nano-Silver
▪️ Nano-Curcumin
▪️ Nano-Quercetin
▪️ Luteolin
▪️ Deoxyribonuclease
▪️ Cape Aloe
Advantages Offered▪️ Minimizes fungal infections
▪️ Supports the well-being of nails and skin
▪️ Alleviates inflammation
▪️ Supplies nourishment to nails
Ideal ApplicationUse a proper amount on the affected area only
Side EffectsNone
Bonuses2 E-guides
Refund60 days
AvailabilityLimited to the NanoDefense Pro official website

A Brief Overview Of NanoDefense Pro

NanoDefense Pro supports healthy nails and skin and upon a detailed examination, I found that it is ideal for anyone suffering from toenail fungus. This is an easy-to-apply solution and I noticed that each bottle contains 15ml for a month’s usage. NanoDefense Pro liquid can also be called a deep-space antifungal solution in which its nano-size ingredients can penetrate the problem areas and provide ultimate relief. I examined its ingredients and found all of them to be nano-size and 100% natural.

These are carefully selected based on research and clinical studies and address the root cause of nail fungus. All the NanoDefense Pro ingredients are safe, non-GMO, and free from toxins and contaminants. It is manufactured entirely inside the United States in state-of-the-art facilities that are certified by the FDA and GMP guidelines for safety and quality.

When I inquired about its purchasing options, I found that the supplement is only available through the NanoDefense Pro official website and you get a 60-day money-back guarantee with every purchase.

How Does NanoDefense Pro Solution Work?

NanoDefense Pro formula works based on adapting the methods of nanotechnology and utilizes it in eradicating the nail fungus from its roots. My research led me to the finding that most fungal infections become pervasive and strong over time even after using certain medications. This is because most of these medications are not able to penetrate the dense mesh-like cocoon surrounding the nail fungus.

I learned that NanoDefense Pro nail care solution uses molecules that are 1000 times smaller than the regular ones and these molecules can delve deeper into the fungus infection. They also can stick to the fungi invaders and make them self-destruct. The solution combines certain nano-ingredients and together they ward off the fungi invaders from their roots.

Pros & Cons Of NanoDefense Pro

As the next step in my investigation into the NanoDefense Pro anti-fungal solution,  I wanted to compare its positives with negatives. So I jotted down some of the pros and cons of this foot microbiome support supplement and you can see that compared to its downsides, the upsides of the formula are high. Here is how it went:


  • Based on nanotechnology.
  • Clinically-selected and precision-based ingredients.
  • Natural formula.
  • Non-GMO, stimulant-free, non-habit causing.
  • Easy to use serum form.
  • United States manufacturing.
  • NanoDefense Pro customer reviews are favorable
  • Facilities set by FDA and GMP guideline


  • Available only through the NanoDefense Pro official website.
  • Discounts might be limited.

NanoDefense Pro Ingredients And Their Roles In Promoting Nail Health

I did a thorough examination of the NanoDefense Pro ingredients and found them to be safe and natural. So in this section, I will provide you with a detailed ingredient analysis.

NanoDefense Pro Ingredients


The nano version of silver, a metal that has been used by humans for centuries, nanosilver has many science-backed therapeutic benefits. As per a study published by the NIH, antifungal solutions infused with nanosilver can be effectively used for onychomycosis. According to the Beyond Pesticides website, nanosilver due to their 1-100 nm size can invade bacteria and other microorganisms in your body. 


A nano-formulation of Curcuma longa, nano-curcumin has antioxidant, anti-inflammatory, and antimicrobial properties. According to the International Journal of Molecular Sciences, curcumin has been found to have potential abilities in treating various skin diseases. This ingredient in the NanoDefense Pro drops is also beneficial for supporting overall nail and skin health.


A flavonoid present in many fruits and vegetables, quercetin has research-backed anti-fungal mechanisms. As per a study published in the International Journal of Applied Pharmaceutics, the antifungal and antibacterial activities of quercetin are explained. Multiple studies have shown that nanoformulations of quercetin have increased skin permeability and hence can be ideal for antifungal supplements.


The NIH lists luteolin as a natural compound found in plants like Camelia sinensis. This is a flavonoid with potent anti-inflammatory properties. A study published in Frontiers in Pharmacology showed that luteolin can prevent UVB-induced skin photoaging.

Cucumber fruit extract

Abundant with vitamins A, and C, and antioxidants, cucumber extract has multiple health benefits. It can act as a skin nourishment agent and can be ideal for nail and skincare routines.

According to studies, cucumber was found to have potential benefits in improving skin health and that’s the sole reason behind including it in the formulation of NanoDefense Pro. 

Cape Aloe

Also known as Aloe ferox, cape aloe has anti-inflammatory and antioxidant properties. It can hydrate, strengthen, and condition your nails. 

Other ingredients included in the NanoDefense Pro nanotechnology solution are Deoxyribonuclease, Chrysin, Glycerin, Palmitoyl oligopeptide, etc.

How To Use NanoDefense Pro Solution?

By examining the supplement label, I could learn more about how to use NanoDefense Pro anti-fungal liquid. As we already know, it is available in easy-to-use serum form with each bottle comprising 15ml of this solution. So I found that the manufacturers recommend you take an appropriate amount of this solution, apply it to the affected area, and massage it for 60 seconds.

NanoDefense Pro Supplement Facts

I also learned that regular application of the NanoDefense Pro drops into the affected area is recommended as this ensures better nutrient absorption and faster results. Make sure your nails and skin are clean before applying the solution. Also, giving due consideration to keeping your feet and skin clean regularly can provide you with maximum results.

NanoDefense Pro Claims VS Facts Report

Being a medical reviewer for the past few months, one thing I learned was to fact-check every single claim made by the supplement manufacturers. So here, I have gone through some of the major claims from NanoDefense Pro manufacturers and have examined them based on a factual analysis.

Claim 1: NanoDefense Pro eliminates toenail fungus

Fact: So the general claim that NanoDefense Pro nail and skin health formula helps to kill off toenail fungus was the first claim that had to be examined. For this purpose, I examined individual ingredients and found out their different properties. Most of these ingredients have anti-fungal properties and hence can beat nail fungus. You can find a relevant study in the ResearchGate journal where curcumin, one of the NanoDefense Pro ingredients, is an effective treatment for onychomycosis. 

Claim 2: The formula nourishes skin and nail health

✅Fact: Another claim that NanoDefense Pro supports nail and skin health was checked. Ingredients in the formula such as cape aloe have skin nourishing properties and hence can be effective in maintaining nail and skin health. You can find associated studies published under NIH.

Claim 3: NanoDefense Pro is free from side effects

✅Fact: I then thoroughly examined NanoDefense Pro nanotechnology solution and any possibility of side effects from it. I found that the supplement is made using natural ingredients and free from stimulants and toxins. It is manufactured inside the United States in facilities that comply with safety and quality standards ensured by the FDA and GMP. Hence I learned that this claim can be true as there are no NanoDefense Pro side effects reported yet.

NanoDefense Pro Manufacturer Details And Quality Standards

I have noticed that evaluating the reputation and transparency of a supplement and its manufacturing facilities is important.  So I double-checked its reputation and found that the manufacturer is trustworthy. Also, unlike other nail health forms in the market,  NanoDefense Pro can’t be purchased through any other means like pharmacies or e-commerce platforms like Amazon.  Currently, it is promoted only through ClickBank, which is an authorized online retailer. 

I found that NanoDefense Pro is not approved by the FDA as the FDA doesn’t have the authority to regulate supplements like this. However, I could understand that it is manufactured entirely inside the United States in facilities that are certified by FDA and GMP guidelines.

Comparison Of NanoDefense Pro With Alternatives

This section of the NanoDefense Pro review will help you evaluate the cost and value comparison of this solution with other similar nail health support supplements.

Metanail Serum Pro and ProNail Complex are two nail formulas that have similarities with NanoDefense Pro. The following table will provide you with more information.

NanoDefense Pro And Alternatives
SupplementNanoDefense ProMetanail Serum ProProNail Complex
EffectivenessEffective, research-backed and fastEffective Effective 
Safety100% safe100% safe100% safe
Possibility of side effects NoneNoneNone
Manufacturing StandardsFDA and GMP-accredited facilitiesFDA and GMP-certified facilitiesFacilities certified by the FDA and GMP

A fair comparison of all three supplements made me realize that all of them have qualities that make them genuine and safe. But in some aspects, NanoDefense Pro is a better option as it combines modern research and natural formulas. Yet, in case of this supplement’s unavailability, you can go for the other two.

NanoDefense Pro Side Effects & Interactions

As most of the supplements that are released in the name of skin health support have received customer complaints, I was a bit doubtful whether NanoDefense Pro nail care drops would pause any such issues. However, upon examining its aspects and evaluating it through various customer feedbacks, I learned- that no considerable NanoDefense Pro side effects have been reported of its application. A few customers have remarked of having some mild itchiness after its application but they noticed it quickly faded away as well.

From the supplement label, I understood that the solution should be used based on certain precautions and warnings. First of all, this is not something to be orally taken so in case you accidentally ingest the solution, contact a Poison Control Center immediately. You should be careful not to bring the NanoDefense Pro serum near your eyes or mucous membranes. If you have wounds or damaged skin, do not apply the solution to it. Also, make sure not to use any bandages or heating pads on the solution.

The next question I had in mind was whether the NanoDefense Pro anti-fungal solution would cause any interactions. Even though it is natural, you should be careful not to mix the application with any other cosmetics or nail ointments. If you want to use any nail health formulas or moisturizers, go for natural ones. But I would suggest that it will be better to seek expert advice before doing so.

Does NanoDefense Pro Have A Money-Back Policy?

The good news is, NanoDefense Pro has a return policy. I found from the official website that every purchase accompanies a 60-day money-back guarantee. This is helpful for those who even after trying the formula are not seeing any considerable improvement.

So all you have to do is contact NanoDefense Pro customer service, make your claim, and get the full refund without any hassles. 

NanoDefense Pro Customer Reviews And Testimonials

Finding out what other customers have to say about it was another major challenge for me. For this, I examined various NanoDefense Pro consumer reports available on the formula through social media handles and the official website.

I found that these customers got drastic relief from toenail fungus after applying the NanoDefense Pro serum. They also claimed to have better and shiny nails and skin. I have added some of the customer testimonials for your information.

“ I have tried a lot of essential formulas for removing toenail fungus. None of them worked. It was at the stage of my life where I had lost all my faith in such supplements, NanoDefense Pro came to me. I tried using this as a last resort. It was unbelievable. Within a month, my nagging toenail fungus infection was relieved. Thanks!”Mathew, 45

“ The nail infection stole all my peaceful moments away from me. The constant need to scratch the affected areas was beyond my control. My doctor suggested I use NanoDefense Pro drops. I am relieved from nail fungus and enjoying the recovery for the past year.”Sarah, 34

“ I always keep my feet tidy. Still, I was infected with this nagging fungus on my toenails. Tried every ointment and drug, but the fungus infection grew further. I came across NanoDefense Pro through an advertisement. Started applying it for the next few weeks and the relief was great! Now I no longer have to worry about toenail fungus!”–  Tom, 56

Expert Opinion On NanoDefense Pro

Based on my professional experience and evaluation of countless customer reviews,  I can assure you that the NanoDefense Pro toenail support formula is a genuine and quality-based nail health supplement. Even though it is natural and safe for application, individual discretion is recommended. You are required to wash your nails before applying the solution.

Also, if you have any existing skin or nail health conditions, consulting a doctor before its application is important. In case you have any wounds or scars on the affected area, seek expert advice before applying the NanoDefense Pro anti-fungal serum. 

Where To Purchase NanoDefense Pro Bottle?

Having discussed every other aspect of NanoDefense Pro nail care formula now is the time to investigate its availability. I could find that, unlike other nail health supplements in the market, this is not available through any usual purchasing methods. You can purchase it only through the official website. And its delivery is solely under the responsibility of one of the trusted online retailers, ClickBank.

NanoDefense Pro’s popularity has led to the formulation of multiple replicas and you should be aware of these fraudulent supplements. So avoid purchasing the supplement from any other sources than the ClickBank retailers. 

NanoDefense Pro Bonuses 

I learned that purchasing NanoDefense Pro bottles entitles you to two free bonuses. The details of these bonuses are given below:

NanoDefense Pro Bonuses 

➡️Bonus#1: The Skin Fix Files: Tips and Tricks for Defeating Eczema, Psoriasis And Other Skin Conditions

You get an ebook worth $55 for absolutely free with the NanoDefense Pro supplement. This ebook provides you with some natural tips and tricks to defeat other skin health conditions such as eczema and psoriasis.

➡️Bonus#2 At Your Expense: America’s Eight Costliest Healthcare Mess-Ups And How To Avoid Them

I found that this bonus ebook acts as a guide to prevent some of the costliest healthcare mess-ups common in America. You will learn more about some of the overpriced medicines, unnecessary treatments, etc through this ebook.

Final Verdict: NanoDefense Pro Reviews

In concluding the points discussed above, NanoDefense Pro can be stated as a credible fungus relief formula. It is made out of clinically proven natural ingredients and works at the root of toenail fungus infection. Based on my professional experience and evaluation of customer feedback, proper individual discretion should be taken before using this formula.

People who are pregnant or breastfeeding need to consult their medical care provider before applying the serum. This applies to those with existing medical conditions and those who are already under any medications. And finally, NanoDefense Pro serum is not a cure for treating any diseases and individual results might vary based on certain factors. 

I believe that the information I’ve provided is clear, and this NanoDefense Pro review assisted in improving your understanding of the supplement.


Q.  Can I do a pedicure after applying the NanoDefense Pro serum on my toenails?

The serum can eliminate toenail fungus and help you get healthy nails and skin. Pedicure helps your feet to stay clean and healthy but try to do it at least after 1-2 hours applying the serum.

Q. Do I need to keep the NanoDefense Pro liquid under a cold temperature?

There is no need to refrigerate the bottles. But do not place it near extreme heat or flame.

Q. Can diabetic people apply NanoDefense Pro to fight fungus?

Yes. It can be applied by diabetic people and there is no harm in doing so.

Q. I had completed nail surgery after an infection. Can I apply the NanoDefense Pro solution?

If you have just completed surgery, it is ideal to consult your doctor before using any other fungus relief formula. 

Q. How many days will it take NanoDefense Pro to reach?

It will take 5-7 business days to ship the supplement inside the United States. 


NCBI (n.d) Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis Available online at: https://pubmed.ncbi.nlm.nih.gov/36099971/

IJMS ( 1996-2024) Potential of Curcumin in the Management of Skin Diseases Available online at: https://www.mdpi.com/1422-0067/25/7/3617

Frontiers (2024) Luteolin Prevents UVB-Induced Skin Photoaging Damage by Modulating SIRT3/ROS/MAPK Signaling: An in vitro and in vivo Studies Available online at: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.728261/full

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