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Can You Mix Creatine With Pre-workout? Is It Better? Check!

The natural substance creatine, which is present in muscles, aids the synthesis of energy during brief but intense workouts like lifting weights. It is a ...

by Jessica Bennet

This article was created after thorough research and has been improved with the assistance of AI technology. Furthermore, our dedicated editorial team has meticulously fact-checked and polished its content for accuracy and clarity.

The natural substance creatine, which is present in muscles, aids the synthesis of energy during brief but intense workouts like lifting weights. It is a popular supplement among athletes and gym-goers to increase strength and performance. 

On the contrary, pre-workout vitamins are made to provide an energy boost before working out. Components like vitamins, amino acids, and caffeine are added to these supplements to boost alertness and endurance during the workout.

In other words, pre-workout vitamins give an energy boost before hitting the gym, while creatine aids with muscle energy. People wonder whether it’s acceptable to combine creatin and pre-workout to gain better results. The quick answer will be yes, as creatin can be mixed with pre-workout drinks to increase its adsorption and effectiveness. 

How Does Creatine Work?

Creatine Working

When creatine is consumed, it enters the muscles and is converted into phosphocreatine. These tiny powerhouse molecules will help during intense exercise. Also, phosphocreatine will be helpful when the muscles need a rapid energy boost to keep working.

Creatine replenishes adenosine triphosphate (ATP), the fuel for the muscles. This provides more energy for workouts, as more ATP means more energy. It helps to push oneself into more exercise.

Another advantage of creatine is that it promotes muscular water retention. Because of this water retention, the muscles will have more volume in their cells, giving the appearance of fuller, more pumped muscles.

In addition to helping with muscular fullness and explosive strength, creatine also facilitates muscle healing. It makes the process of regenerating ATP stores faster, which helps muscles recover more quickly from demanding exercise sessions. 

The uses of creatine supplements include:

  • Increased power
  • Enhances athletic performance
  • Boosts muscle protein synthesis and muscle growth
  • Elevates cognitive performance


Recent meta-analysis research found that, when paired with resistance training, taking a creatine supplement can enhance strength by 1.4% and net lean muscle mass by 0.36% every week. 

Major components of pre-workout supplements

Pre-workout supplements can contain a wide range of substances, each with a distinct function. One of the major components of a pre-workout supplement is caffeine. It stimulates alertness and reduces perceived effort during workouts.

Beta-alanine is the amino acid that increases muscle carnosine levels and helps to prevent lactic acid, delaying muscle fatigue. The brand-chain amino acids consisting of leucine, isoleucine, and valine support muscles to synthesize protein and reduce muscle breakdown.

Citrulline malate; the precursor to nitric acid, taurine; an amino acid with antioxidant properties, tyrosine; an amino acid that supports neurotransmitter production; beetroot extract for nitrates; and some essential vitamins and minerals are the other components of a pre-workout supplement.

Things to remember while mixing creatine and pre-workout

  • Do not exceed the recommended dosages of creatine and pre-workout.
  • Observe the body’s reaction to the mixture. Certain chemicals or stimulants, such as caffeine, may cause increased sensitivity in some people. Increase the intake of water before, during, and after the workout, as both pre-workout and creatine increase the hydration requirements of the body.
  • Check the labels to prevent accidentally taking two doses of creatine, as some pre-workout supplements already include it. 

The results of mixing creatine and pre-workout

Because of its ability to increase muscle mass, creatine has long been a mainstay in the fitness industry. Although it can be taken as a supplement, it is a naturally occurring substance found in fish and meat.

ATP, which is necessary for quick motions and high-intensity workouts, is replenished as the body uses more creatine. Strength, power, and general performance will all increase as ATP levels rise. Additionally, a pre-workout supplement is the best way to begin the fitness path.

It has a strong combination of chemicals, including citrulline, beta-alanine, and caffeine, which are all meant to increase energy, focus, and endurance. Therefore, mixing these two components helps create extraordinary results in the fitness journey. 

However, it is important to note the timing and dosage while mixing the two. The best results from pre-workout and creatine come from timing the intake. Consuming them before working out will result in improved energy, concentration, and endurance during your workout. 

The risks of combining the two supplements

Although creatine and pre-workout mixtures are used by many gym-goers, athletes, and fitness coaches, they are prone to potential risks. Some of them include:

  • Dehydration
  • Digestive issues
  • Overstimulation of the body
  • Kidney strain (rare occasions)


Combining creatine with pre-workout is usually safe because both can significantly aid in achieving your fitness objectives. However, it is crucial to take appropriate safety precautions and procedures to reduce the potential risks.

The prescribed dosages for pre-workout and creatine supplements should always be followed for better results and to reduce the risks. To prevent dehydration while having the mixture, the water intake should be increased. Most importantly, the changes in the body should be noticed and addressed by a professional healthcare provider. It is also a good idea to consult a fitness professional before using any supplements, particularly if you have any medical concerns. 


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